pentobarbital will minimize the level or outcome of naloxegol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with sturdy CYP3A4 inducers is not really suggestedBarbiturates are capable of producing all levels of CNS mood alteration from excitation to delicate sedation, to hypnosis, and deep coma. Overd